22.2% Panacur granules

[Kirkie]

Herpard,

You are about to supply a 500mg per kilo dose to a 2kg tortoise.

This is a reproduction of a correspondence I had several years ago with Kevin Eatwell, a very very good reptile vet. Please consider this and if in doubt, please speak to your vet before administering.


"Panacur is a wormer called fenbendazole. This drug class disrupts tubule formation on worms leading to their*death. However*at high doses it interferes with this process*in the host species. Thus toxic effects are seen and can include bone marrow suppression (and hence immunosuppression) and*gastrointestinal ulceration amongst others. Toxic dosages reported have been in the region of 250 - 400 mg/kg. There is a paper reproting this in feas vipers. The signs are often called 'radiomimetic'. Lethergy and death are signs that* could be seen.
*
I*do not advocate routine worming of tortoises, but instead insist on routine testing*for parasites. Dosages used typically are 100mg/kg as a single dose repeated two weeks later given by stomach tube. However greater*effectiveness is acheived by lower dosages*(25mg/kg) given daily over*a three day period and reducing*any risk of toxicity. The downside is three trips to the vet and increased expense. Dosing may*need to be repeated a month later and it is best to check the faecal egg output of any tortoise to ensure that the worms have been eliminated, particularly prior*to the tortoise going onto a particulate substrate or into the garden. High worm burdens can be seen that can lead to lethergy and anorexia. Accurate weighing of the tortoises and calculations of the drug is important to minimise any risks."

[Herpard]

Okay Thanks.

My mum has taken it back to get a refund (would have used it on the dogs but they've been recently wormed)

Waiting for her to get back so we can try the other pet shops

[EJ]

Bottom line... I don't think there is a manufacturers recommended dosage for herps... as is the case with most... if not all... drugs we use on herps(reptiles and amphibians)

For Panacure(fendbendozole) historic dosage for tortoises has been 100 to 125 mg/kg... weekly for about 3 weeks.

Originally Posted by caledonia

that would be way too much I think

Dosage and administration

Routine treatment of adult dogs and cats

Administer 100mg fenbenbazole per 1 kg (2.2 lbs) bodyweight as a single dose.

Practical dosage recommendations:

1 g sachet /dose
Treats 2kg (4.4lb) bodyweight as a single dose (1.1 – 2.2kg)
1.8 g sachet / dose
Treats 4kg (8.8lb) bodyweight as a single dose (2.2 – 4.4kg)

4.5 g sachet /dose
Treats 10kg (22lb) bodyweight as a single dose (5 – 10kg)



For dogs weighing over 10 kg (22 lbs), additional sachets are required according to the additional bodyweight.

Assess bodyweight as accurately as possible and then administer one or a combination of the above sachets, which most closely doses this bodyweight. The dose should be administered by mixing into the feed.

e.g.
For a 9kg dog = 2kg dose (1g sachet) + 4kg dose (1.8g sachet) + 4kg dose (1.8g sachet).

i.e.
one × 1gram sachet + two × 1.8gm sachets (10kg dose)

or
one × 4.5gram sachet (10kg dose)



Treatment should be repeated when natural re-infection with parasitic worms occurs. Routine treatment of adult animals with minimal exposure to infection is advisable 2 to 4 times per year. More frequent treatment, at 6 to 8 weekly intervals is advisable for dogs in kennels.

Weaned puppies and kittens under six months of age

Administer 50mg fenbendazole per 1 kg (2.2 lbs) bodyweight daily for 3 consecutive days.

Practical dosage recommendations:

1 g sachet /dose
Treats 4kg (8.8lb) bodyweight (minimum weight 2.2kg) dosed daily for three consecutive days (2.2 – 4.4kg)

1.8 g sachet / dose
Treats 8kg (17.6lb) bodyweight dosed daily for three consecutive days (4.5– 8kg)

4.5 g sachet /dose
Treats 20kg (44lb) bodyweight dosed daily for three consecutive days (10– 20kg)



For dogs/puppies weighing over 20 kg (44 lbs), additional sachets are required according to the additional bodyweight.

Assess bodyweight as accurately as possible and then administer one or a combination of the above sachets, which most closely doses this bodyweight. The dose should be administered by mixing into the feed.

N.B. Smaller or unweaned puppies and kittens should be treated with Panacur 2.5% or 10% Liquid or Panacur Paste.

e.g.
For a 9kg dog = 4kg dose (1g sachet) + 8kg dose (1.8g sachet) daily for 3 consecutive days.

i.e.
one × 1gram sachet + one × 1.8gm sachets. (12kg) dose daily for 3 days

or
three × 1gram sachet (12kg dose) daily for 3 days



Puppies should be treated at 2 weeks of age, 5 weeks of age and again before leaving the breeder's premises. Treatment may also be required at 8 and 12 weeks of age. Thereafter, frequency of treatment can be reduced unless the pups remain in kennels where reinfestation occurs more readily.

Pregnant dogs

Administer 25mg fenbendazole per 1kg (2.2lbs) bodyweight daily from day 40 of pregnancy continuously to 2 days post-whelping (approximately 25 days).

Practical dosage recommendations:

1 g sachet /dose
Treats 8kg (17.6lb) bodyweight dosed daily for approx. 25 days

1.8 g sachet / dose
Treats 16kg (35.2lb) bodyweight dosed daily for approx. 25 days

4.5 g sachet /dose
Treats 40kg (88lb) bodyweight dosed daily for approx. 25 days



For bitches weighing over 40 kg, additional sachets are required according to the additional bodyweight.

As this treatment of pregnant dogs is 98% effective, puppies from these dogs should themselves be treated with a 3 day course at 2 and 5 weeks of age with Panacur 2.5% or 10% Liquid or Panacur Paste. Treat the bitch at the same time at the routine adult dose rate (i.e. 100mg/kg as a single dose).

Pregnant cats

Pregnancats can be safely treated with Panacur Granules but only require a single treatment at the routine adult dose rate, as there is no pre-natal transfer of worm larvae in the cat. Administer 100mg fenbendazole per 1kg (2.2lb) bodyweight as a single dose.

Increased dosing for specific infections

For the treatment of clinical worm infestations in adult dogs and cats or Giardia spp. infections in dogs, administer 50mg fenbendazole per 1kg (2.2lbs) bodyweight daily for 3 consecutive days.

For control of lungworm Oslerus (Filaroides) osleri in dogs administer 50mg fenbendazole per 1kg (2.2lbs) bodyweight, daily for 7 consecutive days. A repeated course of treatment may be required in some cases.

For the control of lungworm Aelurostrongylus abstrusus in cats administer 50mg fenbendazole per 1kg (2.2lbs) bodyweight daily for 3 consecutive days.

Contra-indications, warnings, etc

For animal treatment only. Keep out of the reach of children.

Assess bodyweight as accurately as possible before calculating the dosage.

Operator warnings

Direct contact with the product should be kept to a minimum. Wash hands after use.

Environmental warnings

Dispose of used containers and sachets safely.

[Alan1]

Originally Posted by EJ

Bottom line... I don't think there is a manufacturers recommended dosage for herps... as is the case with most... if not all... drugs we use on herps(reptiles and amphibians)

For Panacure(fendbendozole) historic dosage for tortoises has been 100 to 125 mg/kg... weekly for about 3 weeks.

is that for the 22.2% stuff or 2.5% stuff? I think there might be an 18% stuff too

[EJ]

It doesn't make a difference... the dosage is in mg/kg. You have to add another converson factor depending on the percentage of the stuff you are using.

At 22.2% you are looking at 22.2mg of medicine per 100mg of product... at 2.5% you are looking at .025mg of medicine/100mg of product... and so on.

The higher percentage will require less product.

Originally Posted by caledonia

is that for the 22.2% stuff or 2.5% stuff? I think there might be an 18% stuff too